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Formation of a large S1 pocket, comparable to chymotrypsin, is actually popular with solid truck der Waals friendships regarding Met45 using the aliphatic facet chain of Gln53. Whilst Gln53 can be conserved inside ��5i-subunits, it can be swapped out in ��5c-subunits through Ser, which in turn can't support Met45 through hydrophobic friendships. Consequently, ��5c?harbors an extremely more compact

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