In ."Siah2 was recognized from the R7 photoreceptor cells involving Drosophila melanogaster [ 1]. Siah2 features to target various necessary protein substrates for weakening via ubiquitination. From the hypoxia result path, Siah2 mediates productive ubiquitination to regulate the steadiness associated with prolyl hydroxylase (PHD) [ 2]. The particular mammalian genome encodes three strongly associ


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