The suppression of key WT1 isoform-mediated transcriptional activation by Ex4a(+) WT1 is likely to be extended to other direct transcriptional targets in addition as Bcl-xL and Bcl-2. Considering that several other genes dependable for anti-apoptosis these as BFL-1 and c-myc are also recognized as direct transcriptional targets of key WT1 isoforms [16, 17], Ex4a(+)WT1-induced apoptosis might be tr


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